Are these gene therapies?
The FDA states that “human gene therapy seeks to modify or manipulate the expression of a gene or to alter the biological properties of living cells for therapeutic use.”. So as far as we know, no, our DNA isn’t involved. This is because a complex multiple-step process is needed to convert the mRNA into DNA, enter the nucleus, and integrate into the cell’s DNA.
Well, that’s what they have been telling us, but these claims of safety are not backed up by scientific evidence in the literature. As one review of this topic notes, “many studies simply state that vaccine mRNA cannot integrate into the host genome without explaining why this is not possible”.
Retroposition, in genetics, is a term that describes the integration of a sequence from RNA into a DNA genome. mRNA can be reintegrated into the genome via a process called reverse transcription. In fact, retroposition produces a large number of functional genes in the genome and accounts for about 10,000 duplications in the human genome.
One way in which reverse-transcription takes place is via a molecule called long interspersed element-1 (LINE-1 or L1) retrotransposons. And so various mRNAs in humans could be reverse-transcribed and integrated into the genome via L1 retroelements with negative health consequences.
It is important to note that the vaccine mRNA was genetically modified to reduce our immune response to it to enhance translation and stability. And the available information on the vaccine mRNA engineering logic reveals that vaccine mRNAs were not specifically constructed to avoid capture by the L1 retroposition machinery. Additionally, it has been speculated that the sequence length of BNT162b2 mRNA is most likely not going to be a barrier to retroposition because it is extremely close to the typical length of parental genes' mRNA.
In a single 30 μg dose of the shot, there are around 1.3 × 10^13 synthetic mRNA molecules. To put that into perspective, that’s enough to give every nucleated cell in your body about 26 mRNA copies each. And individuals do not receive one heavy dose of stable, immune-evading mRNA, but multiple doses which in turn increases the chances of vaccine mRNA encountering L1 machinery throughout various cell types in the body.
Also, it is important to note that several papers have mentioned that infection of human cells by viruses, including SARS-CoV-2, increases the activity of their endogenous L1 retroelements, and thus paradoxically the likelihood of vaccine mRNA genome integration may be increased by mRNA vaccination during an active viral infection or after it has cleared up.
So far these are all speculations and have not been noted to occur in real life. Not because it does not happen, but because there is an extreme paucity of data. But the absence of evidence is not evidence of absence.
The evidence we do have is not looking good for humanity. One study of host cells in culture noted that reverse-transcribed SARS-CoV-2 RNA could integrate into the genome of cultured human cells and could be expressed in patient-derived tissues. And another lab (in vitro) study showed the uptake of mRNA material from these novel ‘vaccines’ into human liver cell lines.
If more evidence amounts to the fact that DNA integration is possible via these vaccines, then we’re in big trouble. It essentially means that a large subset of the population could produce spike proteins naturally and others may pass this trait on to their children forever. More evidence and better quality evidence is needed before we open that can of worms.
Hopefully you can see why I wince at calling these mRNA agents ‘vaccines’, simply because they are not.